42 articles - From Friday Nov 29 2024 to Friday Dec 06 2024
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Am J Clin Nutr |
|---|
Effects of high-protein supplementation during cancer therapy: a systematic review and meta-analysis. High-protein supplementation mitigates weight loss, improves muscle strength, and lowers hospitalization rates in patients undergoing cancer therapy. These positive clinical outcomes, along with a favorable safety profile, suggest that high-protein supplementation may be a valuable addition to medical practice. However, given the need for more robust trials and the high ROB observed in the existing studies, these conclusions should be interpreted with caution. This review was prospectively registered with PROSPERO under the registration number CRD42021237372. |
| Pancreas |
Evaluating Continuous Glucose Monitoring after Total Pancreatectomy with or without islet autotransplatation: A Scoping Systematic Review. CGM can be used following TP for glucose monitoring and/or linked with insulin pump device in the peri-operative period with improved glycaemic control. However, the data are limited by short follow-up and lack of PROMs and QoL measures. |
The Effect of Epidural Analgesia on In-Hospital Outcomes in Patients with Acute Pancreatitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. EA did not significantly improve in-hospital outcomes in AP patients. However, findings indicated reduced opioid consumption in the EA group, suggesting potential benefits in pain management. Further high-quality, large-scale randomized trials are needed to understand the potential benefits of EA in this population. |
| Pancreatology |
Presentation and management of pancreatic hydatid cyst: A comprehensive systematic review of the literature with meta-data. Although pancreatic hydatid cysts are rare and can be challenging to diagnose, their prognosis is generally favorable when appropriate therapeutic measures are employed. Surgical intervention, often combined with Albendazole, remains the mainstay of treatment. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
|---|
Association of the glucose patterns after a single non-standardized meal with the habitual diet composition and features of the daily glucose profile in individuals without diabetes. Two PPGR patterns after a single non-standardized breakfast were identified in high-cardiometabolic risk individuals. The habitual diet was associated with the patterns and their dynamic parameters, which, in turn, could predict the individuals' DGP. Our findings could support the implementation of dietary strategies targeting the PPGR to ameliorate the cardiometabolic risk profile. Clinical trial id NCT03410719. |
Associations of Life's Essential 8 with Low Muscle Mass Mediated by Testosterone, Inflammation and Nutritional Status in US Adults: A Cross-Sectional Study. LE8 scores negatively associated with low muscle mass in US adults. Serum testosterone in males and SHBG in females were negative predictors of low muscle mass, while SII was inversely associated. Serum albumin had a beneficial effect on muscle mass. |
Dietary plant-to-animal protein ratio and risk of cardiovascular disease in 3 prospective cohorts. In cohort studies of United States adults, a higher plant-to-animal protein ratio is associated with lower risks of CVD and CAD, but not stroke. Furthermore, a higher ratio combined with higher protein density showed the most cardiovascular benefit. |
Food insufficiency, SNAP status, and variability in weight and body composition: Longitudinal analysis of the National Health and Aging Trends Study Cohort 2012 - 2021. Recurring food insecurity was associated with variability in older adults' weight and body composition. Additional interventions, beyond SNAP, are needed to prevent food insecurity and instability in body weight and composition. |
Oral Citrulline supplementation in pregnancies with preeclampsia: a multicentre, randomized, double blind clinical trial. L-citrulline oral supplementation does not seem to be a promising candidate as a therapeutic intervention in pregnancies with preeclampsia. Clinical Trial Registration |
Replacing dietary carbohydrate with protein and fat improves lipoprotein subclass profile and liver fat in type 2 diabetes independent of body weight: evidence from two randomized controlled trials. Replacing dietary carbohydrate with protein and fat improves dyslipidemia in T2D independently of changes in body weight, by inducing an atheroprotective shift in the lipoprotein particle profile possibly facilitated by reduced IHTG accumulation. Clinicaltrials Gov registration NCT02764021; NCT03814694; |
The effect of an intervention to reduce aflatoxin consumption from 6 to 18 months of age on length-for-age Z-scores in rural Tanzania: a cluster-randomized trial. and conclusions An intervention to reduce AF exposure did not alter AF-alb nor anthropometric measures between treatment groups. Drought and agricultural data indicated less favorable conditions for toxin production, resulting in low levels of exposure in both trial arms. Annual, seasonal, and geographic heterogeneity of AF contamination make it difficult to study in an ethically-designed trial. Our formative research and early trial data indicate that stunting and intermittent AF exposure continue to be a problem in this area. However, the low AF exposure levels during the trial led to inconclusive results. |
| Liver Transpl |
Metabolic issues in patients with metabolic dysfunction-associated steatohepatitis (MASH) and their impact on MASH recurrence following Liver Transplantation: A narrative review. Recurrence of MASH following liver transplant can occur due to many reasons including reversal of the catabolic state seen in cirrhosis, improvement in appetite, and the effect of certain post-LT medications on the graft; however, managing recurrence can be challenging and thus urges addressing these issues prior to transplant, in addition to recognizing, and treating them in the post-transplant setting. In this review, we discuss the various metabolic issues that face patients with MASH, the medical and surgical management options available to improve outcomes and reduce chances of recurrence. |
| Pancreas |
Circulating Chromogranin A is associated with disease extent, progression and recurrence in patients with non-functioning pancreatic neuroendocrine tumor (NF-PNET). Serum Chromogranin A correlates with disease extent in NF-PNET, and is useful for surveillance after resection of NF-PNET. |
Circulating biomarkers of macrophage activation in different stages of chronic pancreatitis: A pilot study. Our study demonstrates that subjects with definitive CP, sampled during a clinically quiescent phase, exhibited increased levels of sCD163 and sCD206. This indicates the presence of activated M2 macrophages in patients with CP at advanced, but not early, clinical stages. |
Decisional Control Preferences in Managing Intraductal Papillary Mucinous Neoplasms of the Pancreas. Most patients preferred an active role in IPMN treatment decisions. Lower health literacy and Latino race were associated with a preference for non-active decision roles. Clinicians should strive to align patient involvement in IPMN treatment decisions with their patient's preferred role. |
High Diagnostic Yield of Fine Needle Biopsy for Pancreatic Serous Cystadenomas - a Multi-Center Study. EUS-FNB sampling for histopathology is a safe and accurate diagnostic tool for pancreatic serous cystadenoma. When microcytic lesions are found on endoscopic ultrasound, our study results suggest that fine needle biopsy for histopathology should be considered as the initial diagnostic evaluation tool given the demonstrated improved diagnostic yield for serous cystadenoma. |
INVESTIGATION OF GEOSPATIAL DISPARITIES IN CHRONIC PANCREATITIS OUTCOMES. Despite multidisciplinary guideline-based care, residence in the most vulnerable neighborhoods may be associated with less opioid use and more frequent CP flares, suggesting possible inadequate pain control in these patients. These findings should guide prospective investigation of the impact of geospatial social determinants of health in CP and efforts to mitigate the above disparities. |
Oncogenic KRAS Promotes Ferroptosis in Pancreatic Cancer through Regulation of the FOSL1-TFRC Axis. Furthermore, the KRAS/FOSL1/TFRC axis can make the PDAC cells vulnerable to alteration of the iron level in the tumor microenvironment. Our study highlights a pivotal mechanism of PDAC ferroptosis through iron metabolism and supports a new therapeutic strategy for PDAC with superior potential. |
Phase II randomized controlled trial to evaluate the supportive effect of Koujin (TJ-3020) powder in gemcitabine and nab-paclitaxel-treated unresectable or recurrent pancreatic cancer. In this phase II randomized trial, oral administration of red ginseng powder at 2.0 g per day did not reduce pancreatic cancer patients' fatigue or malaise induced by GnP combination chemotherapy. |
Risk factors for early liver recurrence after pancreatic cancer resection. The risk factors for postoperative early liver recurrence were R-PV, a tumor diameter ≥ 45 mm and pathological venous invasion. Surgery for pancreatic cancer with these factors may require special treatment, such as hepatic arterial injection. |
SOMATOSTATIN ANALOGUES VS ACTIVE SURVEILLANCE IN SMALL PANCREATIC NEUROENDOCRINE TUMORS. Our monocentric experience demonstrated a significant antiproliferative activity of somatostatin analogues in patients with sporadic, non-functionating G1-G2 PanNETs ≤2 cm delaying tumor progression and distant spread in small lesions that sometimes may reveal unpredictable aggressiveness. |
Serum trypsin is a reliable biomarker of pancreas function. On one hand, assessment of trypsin concentration in the serum sensitively and specifically detects pancreas inflammation; whereas on the other hand, declining trypsin levels in serum showed good correlation with direct pancreatic function tests to identify exocrine pancreatic insufficiency. With this comprehensive review, we aimed to evaluate the existing evidence on the utility of trypsin as a continuous biomarker, spanning from acute to chronic pancreatitis and pancreas function, highlighting its potential in monitoring disease evolution on an individual patient level. |
Tumor budding is an independent adverse prognostic factor of pancreatic ductal adenocarcinoma patients treated by resection after preoperative chemoradiotherapy. This study revealed that the presence of tumor budding was an independent adverse prognostic factor in PDAC patients resected after gemcitabine and S1-based CRT. |
| Pancreatology |
Characteristics and prognosis of patients with pancreatic adenocarcinoma not expressing CA19-9: Analysis of the National Cancer Database. CA 19-9 non-expression is associated with distant metastatic disease at diagnosis and with death in resected non-metastatic patients compared to normal-range CA 19-9 levels. This clinically relevant subgroup requires alternative biomarkers, and may need consideration of more extensive preoperative staging and intensive perioperative systemic therapy. |
Circulating necroptosis markers in chronic pancreatitis and pancreatic cancer: Associations with diagnosis and prognostic factors. Circulating levels of MLKL are lower in patients with CP than PDAC. Elevated sST2 levels are associated with pancreatic diseases. Further studies are required to show whether MLKL and sST2 could be useful biomarkers in evaluating pancreatic diseases. |
Development of a core outcome set for recurrent acute and chronic pancreatitis: Results of a Delphi poll. Using the OMERACT framework, we developed a core outcome set for RAP and CP. Future research will focus on identifying validated measures for each domain, facilitating standardized assessments across clinical trials. |
Genotype-based prognosis prediction for MEN1-Related pancreatic neuroendocrine tumors in Korean patients a single-center retrospective study. An individualized follow-up strategy may be necessary, particularly for young patients with truncating mutation in the MEN1 gene. In addition, those with mutations in exons 3 or 10 may require more active surveillance to decrease the risk of progression. |
Progression of resectable pancreatic ductal adenocarcinoma during surgical delay and effects on survival - A propensity score matched study. Progression in tumor size does not seem to affect survival in our study population. In general, surgical treatment delay in up-front resectable patients does not seem to be associated with survival or the risk of recurrence, but the optimal and maximal time to surgery as well as the optimal timing of the follow-up scanning remain unclear. |
YKL-40 as a risk stratification marker in acute pancreatitis: A prospective study. The high YKL-40 - outcome association at both time-points was conditional on concurrent IL-6: uncertain if IL-6 was low, strong if IL-6 was high. Serum YKL-40 is a plausible candidate for further evaluation as an early biochemical indicator of subsequent AP severity, particularly if considered jointly with CRP and/or IL-6. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Am J Clin Nutr |
|---|
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Clin Nutr |
|---|
| Liver Transpl |
| Pancreas |
Letters to the editors and authors’ replies
| Am J Clin Nutr |
|---|
| Pancreatology |